Vaccsbook

mRNA Vaccines - What's Up with That ?

mRNA and DNA: The Basics
mRNA is a complex molecule that contains the instructions, the "code", used by a cell to make a specific protein.
mRNA is itself made from DNA, but only when a new protein is needed.
DNA is a very, very complex molecule that contains the code for every protein that the body needs.

Every cell in the body has a DNA molecule, and it's the same DNA molecule in every cell, regardless of cell type. It's the same in a skin cell, as in a liver cell, as in a brain cell, as a pancreas cell etc.
When a cell needs to make a protein, say a skin cell needs to repair a cut, it accesses that tiny part of its DNA molecule needed to make the skin protein, and creates an mRNA molecule with the same specific code, by a process called Transcription. (The cell then uses the mRNA to make the protein by a process called Translation.)

How does the skin cell know which tiny part of its DNA to select ?
No one knows !.
But there's a noble prize waiting for whoever figures it out.

However, it's vital that only skin cells make skin proteins, and that skin cells don't make brain proteins, brain cells don't make ovary proteins, ovary cells don't make insulin etc., or the body would disintegrate in chaos.


mRNA Vaccines and Immunity.
An essential attribute of the immune system is its ability to distinguish what's a normal part of the human body, called "self", from what is "not-self" (viruses, bacteria, fungi, pollens, etc) . . . so it can attack and eradicate only the not-self .

The immune system doesn't just produce antibodies; it has many components which continuously interact with each other, e.g. B-cells, T-cells, Killer cells, and a group of molecules called the Major Histocompatibility Complex (MHC).

All of the immune system components work closely together to eradicate the not-self, and to destroy any self cells containing not-self, e.g. lung cells infected with a virus !.

The MHC is the key to determining self from not-self, although the MHC sometimes makes mistakes, resulting in diseases such as Lupus, Multiple Sclerosis, Type 1 diabetes, in which the immune system attacks self (these diseases are known as "autoimmune" diseases).

The precise nature of the components of a person's immune system, is itself determined by that person's DNA, and so varies from person to person . . . which likely explains why some people get Lupus or MS or Type 1 diabetes, but others don't.


mRNA Covid Vaccines
mRNA Covid vaccines take the form of a "Lipid Nanoparticle" (LNP), essentially an mRNA molecule inside a fat bubble.

The early hypotheses claimed that:

1. after the LNP is injected, it gets absorbed by muscle cells at the site of injection,
2. the muscle cells process the mRNA into the Covid spike,
3. the Covid spike is then displayed on the surface of each muscle cell,
4. the spike then "stimulates the immune system . . . to make antibodies",
5. and the mRNA/LNP is then immediately degraded and destroyed.

This has resulted in a not-self spike as part of, effectively "infecting", a self muscle cell.
Just how does the immune system know to react against the spike, without attacking the muscle cell ?

Maybe in some people it does know but in others it doesn't, perhaps depending on each persons' genetically-determined MHC.

Studies at various research institutes around the world have shown LNPs, far from being confined to muscle cells, are present in the bloodstream over a month after injection, and absorbed by the majority of human cell types.

Significantly, although invariably overlooked, is the fact that injectable mRNA, whether as a vaccine or any other therapy, completely bypasses the vital, strictly controlled, cell-specific transcription of mRNA from its DNA.

Human blood vessels, from the largest down to the smallest capillaries are lined with "endothelial" cells. A primary function of endothelial cells is to absorb anything passing in the bloodstream, e.g. the vaccine LNPs. The endothelial cells would then make the Covid spike and display it on their cell surface, likely protruding into the bloodstream.

If the immune system attacks these "spiked" endothelial cells of the blood vessels of the brain, or the blood vessels supplying the heart, or the liver, or the kidney . . . .

What's up with that ?


Footnote:
Health system statisticians in all developed countries, together with life insurers and actuaries, have been reporting non-Covid "excess deaths" since shortly after mRNA vaccines were introduced, "excess deaths" being death rates significantly above what would be predicted according to pre-pandemic averages.
Most of these deaths have been attributed to heart attacks (MIs), heart rhythm disturbances (e.g. VFib), or strokes (CVAs).
However, immune-mediated inflammatory responses are likely occuring in all organs (since all organs have blood vessels). This would lead to loss of functioning tissue in organs like the liver and kidney that normally occurs only with advancing age.
It is possible, in years to come, we will see chronic renal failure and cirrhosis of the liver occuring in comparitively young people. A population-wide analysis of basic blood tests of kidney and liver function would identify these problems and allow for secondary prevention.
As of Spring 2024, there is no evidence anything like this is being done.